The use of cannabidiol (CBD), the main non-psychoactive compound derived from cannabis, in human and veterinary medicine has been steadily increasing over the last ten years, despite the lack of scientific evidence of its effectiveness.
Previous research has shown that cannabinoids, such as CBD, can have antitumor effects, but they are highly dependent on cancer type and dosage. Diseases allegedly treated by CBD such as epilepsy or cancer continue to be the focus of research by many scientists. In the world of cancer research, several publications have shown that CBD is cytotoxic against breast, uterine, brain, and leukemia cancers.
CBD can slow the growth of cancer, writes Inverse. Due to the remarkable similarities from a comparative oncological perspective, canine and human gliomas (tumors) are particularly interesting.
Regardless of the type, gliomas are aggressive tumors that are difficult to treat due to their resistance to multimodal treatment, creating the need for a more effective treatment.
Gliomas are tumors that often occur in the brain or spinal cord and begin in glial cells – “sticky” cells that, when functioning normally, surround neurons and help them function. It is estimated that gliomas make up about 30 percent of all brain tumors and 80 percent of malignant tumors.
Only about 36 percent of patients survive such tumors, and in dogs that number is 2 percent. They usually occur in dogs with long noses, such as golden retrievers, but are also common in Boston Terriers, French Bulldogs, Boxers, Scottish Terriers and Old English Shepherds.
A study released Monday based on human and canine cell results suggests that CBD can be used effectively along with other cancer treatments because of its ability to disrupt the functioning of cancer cells. CBD can slow the growth of cancer because it causes mitochondrial dysfunction in cancer cells, the study said.
Mitochondria allow cells to produce energy and continue living.This research was not published in a scientific journal, but was supposed to be presented at the Experimental Biology 2020 conference, which was canceled due to coronavirus.
Chase Gross, the author of this study, believes these results could lead to improved cancer treatments for both humans and pets, who also suffer from brain tumors.